Polynucleotides
Polynucleotides – Advanced Regenerative Skin Therapy
Treatment Overview
Polynucleotides (PNs) are cutting-edge regenerative injectables that work at a cellular level to repair, restore, and rejuvenate the skin. Derived from highly purified DNA fragments, polynucleotides stimulate fibroblasts, improve hydration, reduce inflammation, and activate tissue regeneration.
Unlike fillers or skin boosters that simply hydrate, polynucleotides heal and remodel the skin from within, making them ideal for treating early ageing, sun damage, acne scarring, and delicate areas like under-eyes.
At Gigi’s Skin Lab, we offer a curated selection of the world’s most trusted polynucleotide treatments: Plinest, Nucleofill, Vitaran, and Rejuran — each tailored to specific skin needs.
Benefits of Polynucleotides
- Stimulates natural collagen & elastin production
- Repairs damaged tissue & accelerates cell regeneration
- Reduces fine lines, wrinkles, and scarring
- Improves skin elasticity and firmness
- Hydrates and restores skin balance
- Brightens dull, tired, or stressed skin
- Safe for sensitive areas such as under-eyes
- Suitable for men and women of all skin types
Why Choose Gigi’s Skin Lab?
- Expertly tailored treatments – We match the right polynucleotide to your skin concerns.
- Premium selection – Offering the most clinically proven brands in regenerative aesthetics.
- Advanced techniques – Safe injection methods, even in delicate areas like tear troughs.
- Long-term results – Ongoing cellular repair continues for weeks after each session.
The Experience
- Consultation – We assess your skin and select the most appropriate polynucleotide product.
- Treatment – Small, precise injections deliver polynucleotides directly into target areas.
- Aftercare – Minimal downtime, with slight swelling possible around injection sites (especially under-eyes).
- Results – Progressive improvements in hydration, texture, and firmness over several weeks.
Treatment Plan & Pricing
- Plinest / Nucleofill / Vitaran / Rejuran – from £XXX
- Course of 2–4 sessions recommended, spaced 2–4 weeks apart
- Maintenance: every 6–9 months for sustained results
Skin Boosters Comparison
| Treatment | Main Focus | Key Ingredients / Formula | Best For | Sessions Needed |
|---|---|---|---|---|
|
Profhilo (HA) |
Hydration & bio-remodelling |
64mg Hyaluronic Acid (NAHYCO® Hybrid Technology) |
Fine lines, skin laxity, hydration, face/neck/hands |
2 sessions (4 weeks apart), maintenance every 6 months |
|
PLLACELL (PLLA)
|
Advanced regeneration & collagen stimulation |
35mg Poly-L-Lactic Acid + 8mg Polynucleotides + Glutathione + Vit C + Sodium Hyaluronate |
Volume loss, wrinkles, pigmentation, dullness, repair |
2–3 sessions, maintenance every 6–9 months |
|
Plinest (PN) |
Regeneration & repair |
Polynucleotides (original brand)
|
Texture issues, acne scarring, advanced |
3–4 sessions, maintenance every 6–9 months
|
|
Nucleofill(PN)
|
Lifting & anti-ageing bio-stimulation
|
Polynucleotides (Soft, Medium, Strong strengths)
|
Laxity, firmness, oxidative stress, deeper regeneration
|
2–3 sessions, maintenance every 6–9 months
|
|
Vitaran(PN) |
Hydration & strengthening
|
Next-gen Polynucleotides |
Fragile under-eye/skin, prevention, glow, resilience
|
2–3 sessions, maintenance every 6–9 months
|
|
Rejuran(PN) |
Barrier repair & anti-inflammatory
|
Polynucleotides (Salmon DNA extract) |
Under-eye, sensitive skin, fine lines, early ageing
|
2–3 sessions, maintenance every 6–9 months
|
|
Seventy Hyal (HA) |
Hydration & plumping |
Hyaluronic Acid (non-crosslinked) |
Dehydrated, dull skin, glow, prevention
|
2–3 sessions, maintenance every 4–6 months
|
|
Revs Pro 32 (HA)
|
Hydration & rejuvenation |
32mg Hyaluronic Acid + Amino Acids
|
Tired skin, dullness, first signs of ageing
|
2–3 sessions, maintenance every 4–6 months
|
Polynucleotide Options at Gigi’s Skin Lab
Plinest
- Known as the original polynucleotide product.
- Clinically proven for skin regeneration, wound healing, and scarring.
- Ideal for improving texture, scarring, and skin repair.
Nucleofill
- Advanced biostimulatory injectable available in different strengths (Strong, Medium, Soft).
- Targets hydration, lifting, and tissue regeneration.
- Improves elasticity, firmness, and radiance while reducing oxidative stress.
Plinest
- Known as the original polynucleotide product.
- Clinically proven for skin regeneration, wound healing, and scarring.
- Ideal for improving texture, scarring, and skin repair.
Nucleofill
- Advanced biostimulatory injectable available in different strengths (Strong, Medium, Soft).
- Targets hydration, lifting, and tissue regeneration.
- Improves elasticity, firmness, and radiance while reducing oxidative stress.
Vitaran
- A newer-generation PN with a high safety profile and excellent tolerance.
- Focused on hydration, elasticity, and collagen stimulation.
- Can be used on both face and body areas for rejuvenation.
Rejuran (also called “Rejuran Healer”)
- Popular in Asia, especially Korea, as a skin healer injectable.
- Reduces inflammation, improves texture, and strengthens the skin barrier.
- Effective for under-eye rejuvenation, fine lines, and sensitive skin.
Who Are Polynucleotides Not Suitable For?
- Pregnant or breastfeeding clients
- Those with active skin infections, eczema, or psoriasis in the treatment area
- Clients with uncontrolled diabetes or bleeding disorders
- Individuals with a history of keloid scarring
- Anyone undergoing chemotherapy or radiotherapy
Frequently Asked Questions
Skin boosters focus mainly on hydration, while polynucleotides actively repair and regenerate skin tissue, providing long-term improvements.
Skin looks more hydrated and refreshed within 1–2 weeks, with structural improvements developing gradually over 2–3 months.
Results typically last 6–9 months, with maintenance recommended once or twice per year.
Yes — they are biocompatible, highly purified, and suitable for all skin types.
Yes, polynucleotides are one of the safest and most effective options for the under-eye/tear trough area, improving hollowness, crepey texture, and fine lines.
Absolutely — they pair well with microneedling, skin boosters, and chemical peels for enhanced results.
Yes — it pairs well with skin boosters, mesotherapy, and chemical peels.
